Abstract
The discovery, synthesis and biological evaluation of a novel series of 7-isoxazoloquinolines is described. Several analogs are shown to increase ApoA1 expression within the nanomolar range in the human hepatic cell line HepG2.
Copyright © 2012 Elsevier Ltd. All rights reserved.
MeSH terms
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Animals
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / pharmacology
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Apolipoprotein A-I / metabolism*
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Drug Discovery*
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Hep G2 Cells
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Heterocyclic Compounds, 4 or More Rings / chemistry*
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Heterocyclic Compounds, 4 or More Rings / pharmacology*
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Histone Acetyltransferases
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Histone Chaperones
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Humans
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Inhibitory Concentration 50
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Mice
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Mice, Inbred BALB C
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Nerve Tissue Proteins
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Nuclear Proteins / antagonists & inhibitors*
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Nuclear Proteins / metabolism
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Quinolines / chemistry*
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Quinolines / pharmacology
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Rats
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Structure-Activity Relationship
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Up-Regulation / drug effects*
Substances
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Anti-Inflammatory Agents
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Apolipoprotein A-I
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BRD1 protein, rat
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GSK1210151A
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Heterocyclic Compounds, 4 or More Rings
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Histone Chaperones
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Nerve Tissue Proteins
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Nuclear Proteins
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Quinolines
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quinoline
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BRD1 protein, human
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Histone Acetyltransferases